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Anti-LRWD1 Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Leucine-rich repeat and WD repeat-containing protein 1 |
Synonyms: | CENP-33, DKFZp434K1815, ORCA |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse LRWD1 |
Uniprot ID: | Q8BUI3 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 72 kDa / 90 kDa |
Product Usage Information
WB | Human | 1: 1000-1: 2000 | MCF7, Molt-4 |
Background
Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation (By similarity). Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.
Images
| Western blot analysis of LRWD1 (GB115193) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |