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Anti-LXR alpha Rabbit pAb (100 μl)
| Reactivity: | H & H & H |
| Applications: | WB & IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | LXR alpha rabbit polyclonal antibody |
Gene Name: | Oxysterols receptor LXR-alpha |
Synonyms: | NR1H3, LXR-a, LXRA, RLD-1, Liver X receptor alpha, nuclear receptor subfamily 1 group H member 3 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse LXRα |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: | Q9Z0Y9, Q62685 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1:500-1:2000 | kidney, liver, lung |
Background
Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.
Images
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Immunohistochemistry of paraffin embedded mouse kidney using LXRα (GB11350) at dilution of 1:600 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse liver using LXRα (GB11350) at dilution of 1:600 (400x lens) |
| Immunohistochemistry of paraffin embedded rat kidney using LXRα (GB11350) at dilution of 1:600 (400x lens) |
| Immunohistochemistry of paraffin embedded rat liver using LXRα (GB11350) at dilution of 1:600 (400x lens) |
| Immunofluorescence of paraffin embedded mouse kidney using LXRα (GB11350) at dilution of 1:500 (400x lens) |
| Immunofluorescence of paraffin embedded mouse liver using LXRα (GB11350) at dilution of 1:500 (400x lens) |
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Immunofluorescence of paraffin embedded rat lung using LXRα (GB11350) at dilution of 1:500 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |