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Anti-METTL3 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & M |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | METTL3 rabbit polyclonal antibody |
Gene Name: | N6-adenosine-methyltransferase subunit METTL3 |
Synonyms: | IME4, M6A, methyltransferase like 3, METTL3, MT A70, MTA70, Spo8 |
Immunogen: | Recombinant protein corresponding to Mouse METTL3 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Predicted MW. | 64 kDa |
Observed MW. | 70 kDa |
Uniprot ID: | Q8C3P7 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1:500-1:1500 | brain, testis |
IHC/IF | Mouse | 1:600-1:1200 | testis |
Background
METTL3 is a key S-adenosyl-L-methionine-binding subunit, which is component of a complex multicomponent enzyme that catalyzes the methylation of internal adenosine residues in eukaryotic mRNA, forming N6-methyladenosine. It contains 2 putative nuclear localization signals and 2 consensus methylation motifs. The calculated molecular weight of METTL3 is 64 kDa, but modified METTL3 is about 65-70 kDa.
Images
| Western blot analysis of METTL3 (GB114124) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded mouse testis using METTL3 (GB114124) at dilution of 1: 1200 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |