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| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Ribosomal protein S6 kinase alpha-5 |
Synonyms: | Rps6ka5, RPS6KA5, MSK1, MSPK1, RLPK, ribosomal protein S6 kinase A5 |
Immunogen: | Recombinant protein corresponding to Mouse MSK1 |
Uniprot ID: | Q8C050 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Product Usage Information
IHC/IF | Human, Mouse, Rat | 1: 500-1: 2000 | lung cancer, lung, spleen |
Background
Ribosomal protein S6 kinase alpha-5 is an enzyme encoded by the RPS6KA5 gene. MSK1 is a mitogen and stress activated protein kinase 1 which belongs to the AGC family of kinases and is related in structure to the ribosomal p70 S6 kinase subfamily. MSK1 can be activated by ERK1/2 and SAPK2/p38 MAP kinase. It is also known to be required for the phosphorylation of CREB, ATF1 H3 and HMG14 in response to mitogen and stress.
Images
| Immunohistochemistry analysis of paraffin embedded human lung cancer using RLSK (GB11865) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin embedded mouse lung using RLSK (GB11865) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin embedded rat spleen using RLSK (GB11865) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |