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Anti-Mint3 Rabbit pAb (100 μl)
| Reactivity: | M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Mint3 rabbit polyclonal antibody |
Gene Name: | Amyloid-beta A4 precursor protein-binding family A member 3 |
Synonyms: | Adapter protein X11gamma, Neuron-specific X11L2 protein, Neuronal Munc18-1-interacting protein 3, Mint-3, Apba3, X11L2 |
Immunogen: | Recombinant protein corresponding to Mouse Mint3 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 61 kDa |
Observed MW. | 61 kDa |
Uniprot ID: | O88888 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse | 1: 500-1: 1000 | liver, kidney |
Background
The Beta-Amyloid precursor protein (Beta-APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The Beta-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the Beta-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing Beta-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of Beta-APP. Multiple splice varitents of X11 have been identified, including X11 Alpha (also designated Mint 1), X11 Beta (Mint 2) and X11 (Mint 3).
Images
| Western blot analysis of APBA3 (GB112060) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |