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Anti-P Glycoprotein Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | ATP-dependent translocase ABCB1 |
Synonyms: | ABCB1, CD243, GP170, MDR1, Multidrug resistance protein 1, P glycoprotein 1, P-gp |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human P Glycoprotein |
Uniprot ID: | P08183 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Predicted MW. / Observed MW. | 141 kDa / 150-180 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 300-1: 600 | brain, liver |
Background
The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
Images
| Western blot analysis of P Glycoprotein (GB115178) at dilution of 1: 600 |
| Western blot analysis of P Glycoprotein (GB115178) at dilution of 1: 600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |