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| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Tumor protein 63 |
Synonyms: | TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H p73L, |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human P63 |
Uniprot ID: | Q9H3D4 |
Isotype: | IgG2a,κ |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Product Usage Information
IHC/IF | Mouse, Rat | 1: 500-1: 1000 | breast, skin |
Background
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2.
Images
| Immunofluorescence of paraffin embedded mouse skin using P63 (GB11396) at dilution of 1: 500 |
| Immunofluorescence of paraffin embedded mouse breast using P63 (GB11396) at dilution of 1: 500 |
| Immunofluorescence of paraffin embedded rat skin using P63 (GB11396) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |