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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | P63 rabbit polyclonal antibody |
Gene Name: | Tumor protein 63 |
Synonyms: | TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H p73L, |
Immunogen: | Recombinant protein corresponding to Mouse P63 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: | Q9H3D4, O88898, Q9JJP6 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1:500-1:1000 | brain, eye, kidney, lung, lung cancer, ovarian cancer, skin |
Background
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates RIPK4 transcription (By similarity).
Images
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Immunohistochemistry of paraffin embedded human lung cancer using P63 (GB11396-1) at dilution of 1:600 (400x lens) |
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Immunohistochemistry of paraffin embedded human ovarian cancer using P63 (GB11396-1) at dilution of 1:600 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse brain using P63 (GB11396-1) at dilution of 1:600 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse kidney using P63 (GB11396-1) at dilution of 1:600 (400x lens) |
| Immunohistochemistry of paraffin embedded rat kidney using P63 (GB11396-1) at dilution of 1:600 (400x lens) |
| Immunohistochemistry of paraffin embedded rat lung using P63 (GB11396-1) at dilution of 1:600 (400x lens) |
| Immunofluorescence of paraffin embedded mouse eye using P63 (GB11396-1) at dilution of 1:500 (400x lens) |
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Immunofluorescence of paraffin embedded rat skin using P63 (GB11396-1) at dilution of 1:500 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |