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| Reactivity: | M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | PDK3 rabbit polyclonal |
Gene Name: | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial |
Synonyms: | Pyruvate dehydrogenase kinase isoform 3, Pdk3, CMTX6, GS1-358P8.4 |
Immunogen: | Recombinant protein corresponding to Mouse PDK3 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Predicted MW. / ObservedMW. | 48 kDa / 45 kDa |
Uniprot ID: |
Product Usage Information
WB | Mouse, Rat | 1: 500-1: 1000 | liver, kidney |
IHC/IF | Mouse, Rat | 1: 2000-1: 4000 | heart |
Background
PDK3([Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial) is also named as PDHK3 and belongs to the PDK/BCKDK protein kinase family. It inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. It has 2 isoforms produced by alternative splicing with the molecular weight of 47 and 48 kDa. This protein can exsit as a dimer with the molecular weight of 90 kDa.
Images
| Western blot analysis of PDK3 (GB113485) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded mouse heart using PDK3 (GB113485) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin embedded rat heart using PDK3 (GB113485) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |