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Anti-Pellino 1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | E3 ubiquitin-protein ligase pellino homolog 1 |
Synonyms: | PELI1, Pellino 1, pellino homolog 1 (Drosophila), PRISM, Protein pellino homolog 1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Pellino 1 |
Uniprot ID: | Q8C669 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 46 kDa / 48 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 1000-1: 2000 | brain |
Background
PELI1 encodes pellino-1, an E3 ubiquitin-protein ligase pellino homolog. E3 ubiquitin ligase functions by catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Pellino-1 is involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Pellino-1 can mediate 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation thus playing a role in cellular inflammation. This antibody may cross react with Pellino-3.
Images
| Western blot analysis of PELI1 (GB114136) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |