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Anti-Phospho-EGFR (Y1069) Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Epidermal growth factor receptor |
Synonyms: | EGFR, ERBB, ErbB1, HER1, mENA, Phospho-EGFR (Tyr1045), Phospho-EGFR (Tyr1069), PIG61, Proto oncogene c ErbB 1 |
Immunogen: | KLH conjugated Synthetic phosphopeptide corresponding to Human EGFR(Y1069) |
Uniprot ID: | P00533 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 134/45/77/69 kDa / 175 kDa |
Product Usage Information
WB | Human | 1: 300-1: 500 | A-431 |
Background
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses.
Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF.
Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules.
Images
| WB analysis of Phospho-EGFR(Y1069)(GB115662). |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |