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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | RAGE rabbit polyclonal antibody |
Gene Name: | Receptor for advanced glycatio endproducts |
Synonyms: | AGER, Ager, RAGE, SCARJ1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse RAGE |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Secreted, Cell membrane |
Predicted MW. | 43 kD |
Observed MW. | 48 kD |
Uniprot ID: | Q62151, Q15109, Q63495 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | lung |
Background
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.
Images
|
Western blot analysis of RAGE (GB11278) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |