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Anti-RALBP1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | RalA-binding protein 1 |
Synonyms: | 76 kDa Ral interacting protein, DNP SG ATPase, Ral interacting protein 1, ralA binding protein 1, RALBP1, RIP1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse RALBP1 |
Uniprot ID: | Q62172 |
Isotype: | lgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Cytoplasm, Cytoskeleton |
Product Usage Information
IHC/IF | Human, Mouse, Rat | 1: 150-1: 600 | heart, kidney, lung |
Background
Multifunctional protein that functions as a downstream effector of RALA and RALB. As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity. As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis. During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle. During mitosis, also controls mitochondrial fission as an effector of RALA. Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L. Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin contributing to cell multidrug resistance.
Images
| Immunohistochemistry analysis of paraffin embedded human kidney using RALBP1 (GB115598) at dilution of 1:150 |
| Immunohistochemistry analysis of paraffin embedded human lung cancer using RALBP1 (GB115598) at dilution of 1:150 |
| Immunohistochemistry analysis of paraffin embedded mouse heart using RALBP1 (GB115598) at dilution of 1:150 |
| Immunohistochemistry analysis of paraffin embedded mouse skeletal muscle using RALBP1 (GB115598) at dilution of 1:150 |
| Immunohistochemistry analysis of paraffin embedded mouse testist using RALBP1 (GB115598) at dilution of 1:150 |
| Immunohistochemistry analysis of paraffin embedded rat heart using RALBP1 (GB115598) at dilution of 1:150 |
| Immunohistochemistry analysis of paraffin embedded rat skeletal muscle using RALBP1 (GB115598) at dilution of 1:150 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |