| Reactivity: | H | 
| Applications: | IHC/IF | 
| Host Species: | Rabbit | 
| Clonality: | Polyclonal | 
| Full Name: | S100A12/CGRP rabbit polyclonal  | 
Gene Name:  | Protein S100-A12  | 
Synonyms:  | CAAF1, CAGC, Calgranulin-C, CGRP, EN-RAGE, ENRAGE, MRP6, Neutrophil S100 protein, p6, S100A12  | 
Immunogen:  | Recombinant protein corresponding to Human S100A12/CGRP  | 
Isotype:  | IgG  | 
Purity:  | Affinity purification  | 
Subcellular location:  | |
Uniprot ID:  | 
Product Usage Information
Applications  | Species  | Dilution  | Positive tissue  | 
IHC/IF  | Human  | 1: 2000-1: 4000  | colon cancer, squamous carcinoma of the cervix, spleen  | 
Background
S100A12 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. S100A12 is expressed abundantly in granulocytes, and has been implicated to play an important role on inflammatory reactions in various disease states.
Images
  | Immunohistochemistry analysis of paraffin-embedded human colon cancer using S100A12 (GB113483) at dilution of 1: 4000 | 
  | Immunohistochemistry analysis of paraffin-embedded human squamous carcinoma of the cervix using S100A12 (GB113483) at dilution of 1: 4000 | 
  | Immunohistochemistry analysis of paraffin-embedded human spleen using S100A12 (GB113483) at dilution of 1: 4000  | 
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. | 
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |