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Anti-SYTL2/SLP2 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & H,M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SYTL2/SLP2 rabbit polyclonal |
Gene Name: | Synaptotagmin-like protein 2 |
Synonyms: | Exophilin-4, Sytl2, Slp2, EXO4, CHR11SYT, SLP2A |
Immunogen: | Recombinant protein corresponding to Mouse SYTL2/SLP2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human, Mouse, Rat | 1: 800-1: 1600 | para-cancer stomach, rectum |
IF | Human, Mouse, Rat | 1: 600-1: 1200 | stomach, spleen |
Background
Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive.
Images
| Immunohistochemistry analysis of paraffin-embedded human para-cancer stomach using SYTL2 (GB112767) at dilution of 1: 1600 |
| Immunohistochemistry analysis of paraffin-embedded rat rectum using SYTL2 (GB112767) at dilution of 1: 1600 |
| Immunofluorescent analysis of paraformaldehyde-fixed mouse stomach using SYTL2 (GB112767) at dilution of 1: 1200 |
| Immunofluorescent analysis of paraformaldehyde-fixed rat spleen using SYTL2 (GB112767) at dilution of 1: 1200 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |