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Anti-TORC1 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TORC1 rabbit polyclonal |
Gene Name: | CREB-regulated transcription coactivator 1 |
Synonyms: | Mucoepidermoid carcinoma translocated protein 1 homolog, TORC-1, |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse TORC1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 400-1: 800 | colon, kidney |
Background
CRTC1, also named as MECT1, TORC1, and WAMTP1, belongs to the TORC family. It is a transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. CRTC1 acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. It enhances the interaction of CREB1 with TAF4. CRTC1 regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. It is a potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells.
Images
| Immunohistochemistry analysis of paraffin-embedded mouse colon using TORC1 (GB112935) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin-embedded rat colon using TORC1 (GB112935) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin-embedded rat kidney using TORC1 (GB112935) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |