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Anti-TRIM14 Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Tripartite motif-containing protein 14 |
Synonyms: | KIAA0129, TRIM14, tripartite motif containing 14 |
Immunogen: | Recombinant protein corresponding to Mouse TRIM14 |
Uniprot ID: | Q8BVW3 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 50 kDa / 50 kDa |
Product Usage Information
WB | Human | 1: 1000-1: 2000 | HL-60 |
Background
Plays a role in the innate immune defense against viruses.Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways.Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation.Inhibits the transcriptional activity of SPI1 in a dose-dependent manner Plays an essential role in the innate immune defense against viruses and bacteria.Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways.Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation.
Images
| WB analysis of TRIM14(GB115627). |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |