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| Reactivity: | M,R & M,R | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Applications: | IHC & IF | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Host Species: | Rabbit | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Clonality: | Polyclonal | |||||||||||||||||||||||||||||||||||||||||||||||||||
Product Usage Information
Background TSLP is a 159 amino acid four helix-bundle hemopoietic cytokine that signals through a heterodimeric receptor complex consisting of the human TSLP receptor and the IL-7R alpha-chain. It impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes, enhances the maturation of CD11c ( ) dendritic cells, naive CD4 ( ), and CD8 ( ) T cells into proallergic effectors, and primes dendritic cells to produce large amounts of IL-12 after CD40 ligand stimulation. TSLP influences the regulation of the positive selection of regulatory T cells and maintenance of peripheral CD4 ( ) T cell homeostasis. It induces allergic inflammation by directly activating mast cells and may be involved in the pathophysiology of inflammatory arthritis. Images
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