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Anti-Unrip Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Unrip rabbit polyclonal |
Gene Name: | Serine-threonine kinase receptor-associated protein |
Synonyms: | MAP activator with WD repeats, MAWD, PTWD, STRAP, UNR interacting protein, UNRIP, WD 40 repeat protein PT-WD |
Immunogen: | Recombinant protein corresponding to Mouse Unrip |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 38 kDa |
Observed MW. | 38 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 800 | liver, testis |
Background
STRAP (Serine-threonine kinase receptor-associated protein), also known as MAWD, is a ubiquitous WD40 domain protein, common function of which is to provide a suitable scaffold for coordinating multiprotein complex assemblies and thus, regulate a variety of cellular processes like signal transduction, transcriptional regulation, programmed cell death and so on. STRAP plays a role in the cellular distribution of the SMN complex, which is essential for spliceosomal snRNP assembly in the cytoplasm. STRAP inhibits transforming growth factor-beta (TGF-beta) signaling and enhances tumorigenicity via TGF-beta-dependent and -independent mechanisms. STRAP is up-regulated in several cancers and functions as an oncogene.
Images
 | Western blot analysis of Unrip (GB113519) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |