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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Nitric oxide synthase, inducible |
Synonyms: | HEP NOS, Hepatocyte NOS, Inducible NO synthase, Inducible NOS, INOS, NOS, NOS type II, NOS2A, NOS2, Nitric oxide synthase 2, Hepatocyte NOS, Inducible NO synthase, Inducible NOS |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human iNOS |
Uniprot ID: | P35228 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 131 kDa / 131 kDa |
Product Usage Information
Applications | Species | Dilution | Positive Tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | RAW264.7, L6 |
Background
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM.
Images
| WB analysis of iNOS(GB115703). |
| WB analysis of iNOS(GB115703). |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.15% ProClin300, 100 μg/mL BSA and 50% glycerol. |