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Anti-TCOF1 Rabbit pAb (100 μl)
| Reactivity: | M,R & M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TCOF1 rabbit polyclonal |
Gene Name: | Treacle protein |
Synonyms: | Treacher Collins syndrome protein homolog, Tcof1, MFD1, Mandibulofacial dysostosis |
Immunogen: | Recombinant protein corresponding to Mouse TCOF1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 1400-1: 2800 | prefrontal lobe, cerebellum |
IF | Mouse, Rat | 1: 700-1: 1400 | striatum |
Background
Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.
Images
 | Immunohistochemistry analysis of paraffin-embedded mouse prefrontal lobe using TCOF1 (GB112794) at dilution of 1: 2800 |
 | Immunohistochemistry analysis of paraffin-embedded mouse cerebellum using TCOF1 (GB112794) at dilution of 1: 2800 |
| Immunofluorescent analysis of paraformaldehyde-fixed rat striatum using TCOF1 (GB112794) at dilution of 1: 1400 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |