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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TPK1 rabbit polyclonal |
Gene Name: | Thiamin pyrophosphokinase 1 |
Synonyms: | mTPK1, Thiamine pyrophosphokinase 1, Tpk1, PP20, Placental protein 20 |
Immunogen: | Recombinant protein corresponding to Mouse TPK1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 27 kDa |
Observed MW. | 27 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 2000-1: 4000 | liver, kidney |
Background
TPK1(Thiamin pyrophosphokinase 1) is also named as PP20(placental protein 20) and belongs to the thiamine pyrophosphokinase family. It is a cellular enzyme involved in the regulation of thiamine metabolism and catalyzes the conversion of thiamine, a form of vitamin B1, to thiamine pyrophosphate (TDP, or TPP). There is no difference in TPK1 expression in cultured fibroblasts from normal subjects or from patients with thiamine-responsive megaloblastic anemia. It can exsit as a dimer. Defects in TPK1 are the cause of thiamine metabolism dysfunction syndrome type 5, episodic encephalopathy type (THMD5).
Images
 | Western blot analysis of TPK1 (GB112757) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |