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| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TTL rabbit polyclonal |
Gene Name: | Tubulin--tyrosine ligase |
Synonyms: | TTL, Ttl |
Immunogen: | Recombinant protein corresponding to Mouse TTL |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoskeleton |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 2000-1: 4000 | striatum, skeletal muscle, substantia nigra |
Background
Tubulin-tyrosine ligase (TTL) is the enzyme responsible for the reversible addition of a tyrosine residue at the carboxyl end of alpha-tubulin. TTL forms stable complexes with tubulin and inhibit tubulin polymerization. TTL is frequently suppressed during tumor progression with resulting accumulation of detyrosinated alpha-tubulin in tumor cells. TTL suppression in human cancers is associated with increased tumor aggressiveness.
Images
| Immunohistochemistry analysis of paraffin-embedded mouse striatum using TTL (GB112751) at dilution of 1: 4000 |
| Immunohistochemistry analysis of paraffin-embedded rat skeletal muscle using TTL (GB112751) at dilution of 1: 4000 |
| Immunohistochemistry analysis of paraffin-embedded rat substantia nigra using TTL (GB112751) at dilution of 1: 4000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |