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| Reactivity: | Human, Mouse |
| Applications: | WB, IHC, ELISA |
| Host Species: | Rabbit |
| Clonality: | Polyclonal antibody |
| Gene Name: | UL16 binding protein 1 |
| Gene Symbol: | ULBP1 |
| Synonyms: | N2DL-1; RAET1I; NKG2DL1; ULBP1 |
| Gene ID: | 80329 |
| UniProt ID: | Q9BZM6 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-216 of human ULBP1 (NP_079494.1). |
| Dilution: | WB 1:1000-1:2000; IHC 1:100-1:500 |
| Purification Method: | Affinity purification |
| Concentration: | 7.06 mg/ml |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-ULBP1 antibody |
Background
The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene.
Images
 | Western blot analysis of lysates from Raji cells, using ULBP1 Rabbit pAb (A10483) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry analysis of paraffin-embedded Human tonsil using ULBP1 Rabbit pAb (A10483) at dilution of 1:500 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Bufferr (pH 6.0) prior to IHC staining. |
 | Immunohistochemistry analysis of paraffin-embedded Mouse spleen using ULBP1 Rabbit pAb (A10483) at dilution of 1:500 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Bufferr (pH 6.0) prior to IHC staining. |
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