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Anti-WDFY2 Rabbit pAb (100 μl)
| Reactivity: | M |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | WD repeat and FYVE domain-containing protein 2 |
Synonyms: | ZFYVE22 |
Immunogen: | Recombinant protein corresponding to Human WDFY2 |
Uniprot ID: | Q96P53 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Endosome |
Product Usage Information
IHC/IF | Mouse | 1: 1500-1: 3000 | cerebellum, substantia nigra |
Background
Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2.Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1.Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates.Participates in transferrin receptor endocytosis.
Images
| Immunohistochemistry analysis of paraffin embedded mouse cerebellum using WDFY2 (GB114233) at dilution of 1: 2000 |
| Immunofluorescence analysis of paraffin embedded mouse substantia nigra using WDFY2 (GB114233) at dilution of 1: 1500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |