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| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | General transcription and DNA repair factor IIH helicase subunit XPD |
Synonyms: | BTF2 p80, COFS2, CXPD, EM9, ERCC2, TFIIH 80 kDa subunit, TFIIH p80, TTD, XPD, XPDC |
Immunogen: | Recombinant protein corresponding to Human XPD |
Uniprot ID: | P18074 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 87 kDa / 80 kDa |
Product Usage Information
WB | Human | 1: 1000-1: 2000 | HeLa, K562, 293, A-431, MCF7, Hep G2 |
Background
The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Images
| Western blot analysis of XPD (GB114207) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |