Adenovirus DUSP6 (200 µl)

Adenovirus DUSP6 (200 µl)

Cat. #: M1082
Availability: In Stock
$685.00
-+
Description: Human Adenovirus Type5 (dE1/E3) expressing Dual Specificity Phosphatase 6 (DUSP6) under CMV promoter.
Gene: Dual Specificity Phosphatase 6
NCBI Acc. #: BC003143
Gene ID: 1848
GI Number: 13111942
Fusion Tag: C-terminus V5 epitope
Promoter: CMV
Titer: 1E+10~1E+11 PFU/ml
Storage Buffer: DMEM with 2.5% BSA, 2.5% glycerol
Background:   DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associatedwith cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Twotranscript variants encoding different isoforms have been found for the DUSP6 gene.
Documents:   Request a manual/MSDS

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